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MENLO PARK, Calif., July 18, 2012 (GLOBE NEWSWIRE) — Pacific Biosciences of California, Inc. (Nasdaq:PACB) will hold its quarterly conference call to discuss 2nd Quarter 2012 financial results on Thursday, July 26, at 4:30pm Eastern Time.

The call will be webcast and may be accessed at Pacific Biosciences’ website at: http://investor.pacificbiosciences.com/.

Date: July 26, 2012

Time: 4:30pm ET

Listen via Internet: http://investor.pacificbiosciences.com/

Toll-free: 888.366.7247

International: 707.287.9330

Replay: http://investor.pacificbiosciences.com

About Pacific Biosciences

Pacific Biosciences of California, Inc. (Nasdaq:PACB) offers the PacBio^®RS, a high resolution genetic analyzer, to help scientists solve genetically complex problems. Based on its novel single molecule, real-time (SMRT^®) technology, the company’s products enable: targeted sequencing to more comprehensively characterize genetic variations; de novo genome assembly to more fully identify, annotate and decipher genomic structures; and DNA base modification identification to help characterize epigenetic regulation and DNA damage. By providing access to genetic information that was previously inaccessible, Pacific Biosciences enables scientists to increase their understanding of biological systems.

CONTACT: Pacific Biosciences
         Trevin Rard
         650.521.8450
         ir@pacificbiosciences.com